Keith T Flaherty Selected Research

Mitogen-Activated Protein Kinases

1/2019	Adverse events associated with encorafenib plus binimetinib in the COLUMBUS study: incidence, course and management.
1/2017	Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors.
1/2017	An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.
8/2016	Subretinal Fluid Associated With MEK Inhibitor Use in the Treatment of Systemic Cancer.
3/2016	Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy.
1/2014	MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition.
7/2013	TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma.
10/2012	MEK and RAF inhibitors for BRAF-mutated cancers.
2/2012	p53 rescue through HDM2 antagonism suppresses melanoma growth and potentiates MEK inhibition.
12/2010	COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.

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Keith T Flaherty Research Topics

Disease

215	Melanoma (Melanoma, Malignant) 10/2022 - 03/2004
156	Neoplasms (Cancer) 10/2022 - 04/2003
24	Neoplasm Metastasis (Metastasis) 01/2022 - 12/2009
23	Renal Cell Carcinoma (Grawitz Tumor) 01/2022 - 11/2005
22	Disease Progression 01/2022 - 08/2009
8	Breast Neoplasms (Breast Cancer) 01/2022 - 03/2006
7	Brain Neoplasms (Brain Tumor) 01/2021 - 12/2009
7	Fatigue 01/2020 - 04/2004
7	Exanthema (Rash) 01/2020 - 06/2006
7	Hypertension (High Blood Pressure) 10/2018 - 11/2005
7	Neutropenia 03/2014 - 04/2003
5	Thrombocytopenia (Thrombopenia) 02/2005 - 04/2003
4	Inflammation (Inflammations) 01/2022 - 07/2014
4	Nevus (Nevi) 06/2021 - 06/2006
4	Fever (Fevers) 01/2021 - 11/2012
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 04/2010
4	Adenocarcinoma 01/2021 - 01/2017
4	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 04/2010
4	Nausea 01/2020 - 04/2004
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/2014 - 06/2011
4	Keratoacanthoma 03/2014 - 06/2011
3	Lymphoma (Lymphomas) 10/2022 - 01/2020
3	Colonic Neoplasms (Colon Cancer) 01/2020 - 07/2015
3	Kidney Neoplasms (Kidney Cancer) 01/2020 - 01/2007
3	Uveal melanoma 12/2018 - 10/2013
3	Arthralgia (Joint Pain) 10/2018 - 06/2011
3	Glioblastoma (Glioblastoma Multiforme) 09/2016 - 04/2010
2	Pigmented Nevus (Melanocytic Nevus) 06/2021 - 09/2015
2	COVID-19 01/2021 - 10/2020
2	Skin Neoplasms (Skin Cancer) 01/2020 - 04/2010

Drug/Important Bio-Agent (IBA)

52	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021 - 05/2006
34	VemurafenibIBA 01/2021 - 08/2010
33	Sorafenib (BAY 43-9006)FDA Link 01/2020 - 03/2006
29	Pharmaceutical PreparationsIBA 01/2020 - 07/2007
24	trametinibIBA 01/2022 - 07/2012
24	Biomarkers (Surrogate Marker)IBA 01/2022 - 03/2010
23	Immune Checkpoint InhibitorsIBA 01/2022 - 03/2013
22	dabrafenibIBA 01/2022 - 01/2011
18	Phosphotransferases (Kinase)IBA 01/2021 - 03/2008
14	Mitogen-Activated Protein KinasesIBA 01/2019 - 05/2006
13	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2014
10	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2022 - 12/2009
10	Proteins (Proteins, Gene)FDA Link 10/2020 - 06/2006
10	IpilimumabIBA 01/2018 - 01/2012
10	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2016 - 03/2006
9	Carboplatin (JM8)FDA LinkGeneric 01/2016 - 09/2003
9	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2016 - 08/2009
8	AntigensIBA 01/2022 - 07/2010
8	binimetinibIBA 01/2022 - 08/2016
8	Biological ProductsIBA 10/2021 - 04/2010
8	Paclitaxel (Taxol)FDA LinkGeneric 01/2016 - 09/2003
7	Sunitinib (Sutent)FDA Link 01/2020 - 07/2007
7	Dacarbazine (DIC)FDA LinkGeneric 01/2020 - 06/2011
6	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2012
6	encorafenibIBA 01/2022 - 01/2018
6	LigandsIBA 01/2018 - 06/2006
6	CytokinesIBA 01/2018 - 07/2009
5	cobimetinibIBA 01/2021 - 01/2018
5	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 11/2019 - 01/2007
5	Transcription Factors (Transcription Factor)IBA 01/2019 - 01/2013
5	raf KinasesIBA 08/2017 - 03/2006
5	Imatinib Mesylate (Gleevec)FDA Link 08/2015 - 07/2008
4	InterferonsIBA 01/2022 - 03/2009
4	Interleukin-2 (IL2)IBA 06/2021 - 06/2014
4	Gemcitabine FDA Link 01/2020 - 09/2003
4	Monoclonal AntibodiesIBA 11/2019 - 03/2007
4	Proto-Oncogene Proteins B-rafIBA 01/2019 - 09/2010
4	Microphthalmia-Associated Transcription FactorIBA 01/2019 - 10/2014
4	PLX 4720IBA 08/2017 - 01/2012
4	AntibodiesIBA 09/2015 - 06/2006
4	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 09/2015 - 05/2006
4	Bevacizumab (Avastin)FDA Link 08/2015 - 05/2008
4	Angiogenesis InhibitorsIBA 01/2013 - 04/2008
3	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2022 - 12/2012
3	B7-H1 AntigenIBA 01/2022 - 09/2017
3	Temozolomide (Temodar)FDA LinkGeneric 01/2022 - 06/2009
3	spartalizumabIBA 01/2022 - 10/2020
3	Phosphoric Monoester Hydrolases (Phosphatases)IBA 10/2020 - 01/2016
3	TensinsIBA 10/2020 - 01/2016
3	Differentiation AntigensIBA 01/2020 - 01/2013
3	NivolumabIBA 01/2020 - 10/2013
3	Drug CombinationsIBA 01/2019 - 08/2017
3	pembrolizumabIBA 01/2018 - 10/2013
3	Small Interfering RNA (siRNA)IBA 09/2016 - 01/2013
3	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2016 - 01/2013
3	Tyrosine (L-Tyrosine)FDA Link 03/2012 - 10/2008
3	Cyclin-Dependent Kinase 4IBA 01/2012 - 07/2008
3	Cisplatin (Platino)FDA LinkGeneric 06/2009 - 04/2003
2	CohesinsIBA 01/2022 - 01/2016
2	Messenger RNA (mRNA)IBA 01/2022 - 01/2014
2	Death Domain ReceptorsIBA 01/2022 - 01/2020
2	Axitinib (AG 013736)IBA 01/2022 - 11/2019
2	toripalimabIBA 01/2022 - 11/2019
2	EpitopesIBA 01/2021 - 01/2018
2	Hormones (Hormone)IBA 01/2021 - 01/2016

Therapy/Procedure

152	Therapeutics 10/2022 - 03/2004
34	Immunotherapy 01/2022 - 04/2006
16	Drug Therapy (Chemotherapy) 11/2019 - 04/2006
3	Precision Medicine 01/2018 - 02/2014
2	Neoadjuvant Therapy 01/2021 - 01/2019